For whom?

Children with suspected brain tumors and/or therapy-resistant epilepsy.

What is being done?

The use of nTMS and tractography is part of the routine preparation in adult neurosurgery. In Germany, we are the only center that researches the use of these innovative technologies in children with brain tumors and/or therapy-resistant epilepsy. The peculiarities of technical application and interpretation have been summarized in several publications. In future analyses, we plan to investigate the plasticity (= adaptation of the brain to certain circumstances/diseases) of language function in order to better assess the risk of epilepsy surgical procedures on the one hand and to provide a valid alternative to the invasive WADA test on the other.

How does it work?

We perform a preoperative analysis (= before the operation). This is based on mapping the surface of the brain using navigated transcranial magnetic stimulation (nTMS). This means that areas on the surface of the brain that are important for motor and speech functions can be identified with this examination technique and preserved during the subsequent operation. For this purpose, we combine nTMS with diffusion tensor imaging (DTI) fiber tractography. Through the individualized information provided by nTMS, we can visualize the fiber tract network of motor and language functions for each patient.

What is involved in participating in the study?

Participation in the study involves an nTMS mapping, which takes place at the Campus Mitte and lasts between 30 to 60 minutes. Our study team has already gained a lot of experience in treating children and can thus respond to the needs of young patients in a targeted manner.

What are the benefits of participating in the study?

The study currently evaluates the relationships in pediatric patients, so we cannot promise you individual benefits. However, the precise visualization of the fiber tract network enables surgeons to better plan and understand individual cases and, based on this information, plan the operation more effectively.

How can I participate in the study?

If you are interested in participating, please contact your treating neurosurgeon or a member of the study team for further information.