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Darstellung eines Gehirns mit Tumor und Fasertrakten

Risk Assessment of Motor Skills and Language

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For whom?

Patients with a suspected brain tumor in a motor or speech relevant area, who are at least 18 years old.


What is done?

In the neurosurgical clinic, we have been researching for years on how to improve the planning and execution of brain tumor surgeries. The goal of these projects is to remove cerebral space-occupying lesions as completely as possible without causing new neurological deficits.

To achieve this, we perform a preoperative analysis, based on mapping the brain surface using navigated transcranial magnetic stimulation (nTMS). This means that areas of the brain surface that are important for motor skills and language can be identified using this examination technique and spared during the subsequent operation.


How does it work?

For each brain tumor surgery, we create an individualized plan to find the right balance between complete tumor removal and maintaining physical integrity. To achieve this, we combine nTMS with diffusion tensor imaging (DTI) fiber tractography. Using the individualized information from nTMS, we can map the fiber network of motor skills and language.


What effort is involved in participating in the study?

The required MRI imaging is a standard procedure for preparing for the operation. Additionally, we would perform a non-invasive nTMS mapping, which takes about 30 to 60 minutes. For study participation, brief neurological examinations and tests would be added, which would be repeated after the operation during the clinical stay or in the context of follow-up appointments and would last approximately 20-30 minutes.


What advantages does participation in the study offer?

The precise mapping of your fiber network supports the surgeons in the planning and execution of the operation. It also informs them where particular caution should be taken in deeper brain regions, and where tumor removal can be carried out without increased risk. This helps to find the right balance between complete tumor removal and maintaining physical integrity for each patient individually.


How is participation in the study possible?

If you are interested in participating, please contact your attending neurosurgeon or a member of the study team for more information.

Contact Person

Dr. med. Tizian Rosenstock

Resident PhysicianCharité - Universitätsmedizin Berlin

Postal address:Charitéplatz 110117 Berlin

Campus / internal address:Bettenhochhaus, Luisenstr. 64